Endocrine Abstracts

Potassium channels control the membrane voltage of aldosterone-producing zona glomerulosa cells in the adrenal glands. They are necessary for the unique K+ sensitivity of these cells and targets of angiotensin II signaling. The 2-P-domain K+ channels TASK1 and TASK3 are among those K+ channels that exhibit strongest expression levels in the adrenal gland. Knockout mice for TASK1 and TASK3 have highlighted the functional relevance of these channels: In young mice before puberty...